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Rescue of an HSV-1 s17 Δ22 BAC produces multiple coding changes affecting amino acids in conserved box III of VHS. (A) Line drawing of the HSV-1 VHS gene open reading frame denoting the 4 conserved boxes (I to IV) and the VP16 binding domain (9, 27). (B) Amino acid variations identified in the original Δ22 virus, Δ22 viruses derived from a s17 BAC, the revertant of Δ22 (Δ22Rev), and strain F. Sequences have been compared to s17REF.
