Figure 3.
Experiment 2: Rats characterized as addict-like (3crit, n=5) showed higher responses than non-addict-like animals (0crit, n=7) in each criterion for addiction-like behavior. (a) Motivation for cocaine intake expressed by the break point during a progressive ratio session. (b) Persistence of cocaine-seeking expressed by active nose-pokes when the drug is signaled as unavailable. (c) Resistance to punishment expressed by % of baseline active pokes (AP) when cocaine-seeking and taking are paired with a foot-shock punishment (0.2 mA). (d) Addict-like rats had a higher cocaine-use severity as measured by computation of the three criteria in a single addiction score scale. Data are presented as mean±SEM.