Skip to main content
. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: Science. 2012 Oct 4;338(6108):818–822. doi: 10.1126/science.1226191

Fig. 1.

Fig. 1

IRE1α is necessary and sufficient for CASP2 upregulation. (A and B) Immunoblot for full length (FL) CASP2 and cleaved (Clvd) CASP2 in WT and DKO MEFs after BFA treatment. (C) Annexin-V directed FACS analysis of WT and DKO MEFs treated with BFA. (D) CASP2 immunoblot in UPR sensor deficient MEFs treated with BFA. (E) CASP2 immunoblot of Ire1α+/+ and Ire1α −/− MEFs treated with tunicamycin (Tn) or thapsigargin (Tg). Each data point represents the mean value ± SD from three independent experiments.