FIGURE 5.
Concentrations of active NFATc2 were decreased and concentrations of IκB were increased in brains of male APP/PS1 mice supplied with 0.625% pomegranate in their normal drinking water for 3 mo of treatment compared with 12- and 15-mo-old male control APP/PS1 mice provided normal drinking water. (A) Western blot analyses of hippocampal lysates and corresponding quantitated ODs of p-NFATc2 (B) and p-IκB (C) were normalized against NFATc2 and IκB, respectively. OD values ± SDs were averaged and graphed, n = 4. Means without a common letter differ, P < 0.05. APP/PS1, amyloid precursor protein/presenilin 1; C-15, 3-month study, 15-month-old control mice; IκB, nuclear factor of κ light polypeptide gene enhancer in B-cell inhibitor; NFATc2, nuclear factor of activated T cells cytoplasmic 2; p-, phosphorylated; P-15, 3-month study, pomegranate-fed 15-month-old mice; 12, untreated 12-month-old control mice.