Fig. 4.
α5GABAARs expressed in human embryonic kidney 293 cells generate low-amplitude, slowly desensitizing current. (A) Representative traces of GABA-evoked currents recorded from α5β3γ2L, α1β3γ2L, and α1β2γ2L GABAARs. The solid line denotes the duration of GABA application (600 μM). Currents from α5β3γ2L and α1β3γ2L GABAARs are normalized and superimposed for illustration purposes (Lower Right). (B and C) Ip and Iss are reduced for α5β3γ2L vs. α1β3γ2L. (D) The Iss/Ip ratio is greater for α5β3γ2L than for α1β3γ2L GABAARs (*, P < 0.05).