Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Aug 5;202(3):563–577. doi: 10.1083/jcb.201301001

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Liou et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 1. — Depletion of macrophages blocks pancreatic ADM. (A) Samples of human pancreatitis or adjacent normal tissue were stained by immunofluorescence for macrophages (EMR1), amylase, CK-19 (gray in A6), and DAPI as indicated. Bars, 20 µm. (B) FVB mice were treated with control vehicle, GdCl₃, caerulein, or a combination, as indicated (detailed method in Materials and methods section). Pancreata were harvested and IHC stained with H&E or the macrophage marker F4/80. Boxes in A and B indicate enlarged regions. (C) Quantitation of ADM events per field of n = 5 samples from B. The asterisk indicates statistical significance as determined by the Student’s t test. Error bars show means ± SD. (D, top row) Immunofluorescence staining of F4/80, amylase, and DAPI in samples from FVB mice treated with control vehicle, GdCl₃, caerulein, or a combination, as indicated (detailed method in Materials and methods section). (second row) F4/80 channel alone in white. (third row) Immunofluorescence staining of CK-19, amylase, and DAPI. (fourth row) CK-19 channel and DAPI. Bars, 25 µm. See also Fig. S1.