Figure 9.
Multiple episode initiations are the key driver of high shedding rate. (A) High episode rate predicts high shedding rate to a greater extent than (B) high mean episode duration (which is a summary measure of mucosal control). Parameter values that allow more frequent initiation of shedding episodes in the genital tract such as (C) high release rate of HSV from neurons into genital skin and (D) low clearance rate of free HSV particles from the genital tract, are most predictive of high shedding rate.