Figure 8.
CD8+ T-cell influenced parameters that are important mediators of short-term viral control have only a limited impact on long-term shedding rates. (A) CD8+ T-cell expansion rate expansion rate predicts slightly lower shedding rate. (B) HSV DNA replication rate has no impact on shedding rate. (C) CD8+ T-cell regional co-dependence, a model parameter that dictates the range over which these cells provide protection, has no impact on shedding rate. (D) Longer CD8+ T-cell half-life weakly predicts lower shedding rate.