Table 1.
Top 20 validated hits
| FlyBaseID | Symbol | Primary screen average fold change | Validation screen fold change | Fertility | Comments | ||
|---|---|---|---|---|---|---|---|
| Gypsy | Zam | Gypsy3 | |||||
| FBgn0028411 | nxt1 | 2 | 2452 | 3566 | 41 | − | Involved in mRNA export from nucleus |
| FBgn0000928 | fs(1)Yb | 11 | 96 | 700 | 335 | + | piRNA pathway component |
| FBgn0041164 | armi | 48 | 197 | 846 | 112 | + | piRNA pathway component |
| FBgn0261266 | zuc | 19 | 809 | 549 | 9 | + | piRNA pathway component |
| FBgn0263143 | vret | 4 | 74 | 315 | 22 | + | piRNA pathway component |
| FBgn0036826 | CG3893 (asterix) | 42 | 80 | 207 | 10 | + | Contains two CHHC zinc fingers |
| FBgn0016034 | mael | 3 | 159 | 452 | 16 | + | piRNA pathway component |
| FBgn0033273 | CG2183 | 4 | 173 | 158 | 11 | + | Fly homolog of GASZ |
| FBgn0029800 | lin-52 | 5 | 153 | 153 | 8 | + | dREAM complex subunit |
| FBgn0038016 | MBD-R2 | 16 | 85 | 48 | 4 | + | NSL complex subunit |
| FBgn0029113 | uba2 | 3 | 84 | 12 | 8 | + | Sumoylation E1 ligase |
| FBgn0034617 | CG9754 | 2 | 26 | 61 | 14 | + | No conserved domains |
| FBgn0027499 | wde | 3 | 40 | 120 | 12 | + | Co-factor of Eggless |
| FBgn0021761 | nup154 | 6 | 30 | 186 | 3 | + | Structural constituent of nuclear pore |
| FBgn0003612 | Su(var)2-10 | 2 | 9 | 20 | 4 | − | dPIAS, putative SUMO E3 ligase |
| FBgn0001624 | dlg1 | 2 | 16 | 2 | 1 | + | Guanylate kinase |
| FBgn0003401 | shu | 7 | 14 | 416 | 1 | + | piRNA pathway component |
| FBgn0038739 | CG4686 | 4 | 13 | 1 | 1 | + | Part of ribokinase/pfk B and DUF423 superfamilies |
| FBgn0038609 | nup43 | 3 | 12 | 3 | 1 | + | WD40-repeat-containing domain |
| FBgn0038925 | cchl | 0 | 12 | 1 | 2 | + | Cytochrome C heme lyase |