Figure 2. Effect of Azithromycin on Local and Systemic Bacterial Infection.
A single administration of azithromycin (20 mg/mL i.p.) 4 hours following inoculation of the burn wound significantly reduced P. aeruginosa infection both at the burn site and systemically in the lung and spleen (Figure 2a, mean +/− 95% CI. ∞P=0.05, #P<0.001, *Spleen P<0.05). Graphs reflect N=15 from 5 replicate experiments. (NS, normal saline control; AZM, azithromycin; *P<0.05, #P<0.01).
Azithromycin group trended toward greater weight recovery at 72 hours following challenge but this was not statistically significant (Figure 2b). Azithromycin did not significantly affect the number of circulating neutrophils in the peripheral blood or neutrophil accumulation at the site of injury (2c) measured at 72 hours.