Figure 7.
Inhibition of spontaneous metastasis of a mouse mammary carcinoma cell line by EcSOD. (a) Representative bioluminescence images showing the progression of mouse mammary carcinoma cells, 4T1.luc in BALB/c mice at day 10 post tumor implantation (1), 7 days post tumor removal (2), and lung and lymph node metastasis at 4 weeks post tumor removal (3). (b) Occurrence of metastasis of 4T1.luc cells to secondary sites (lungs and lymph nodes) were scored and shown as percent metastasis. (c) Kaplan–Meier survival rate of the AdEmpty, AdEcSOD and AdΔHBD-transduced animals were plotted using Prism stats program with the days elapsed following surgical removal of 4T1.luc primary tumors. Survival curve for AdEcSOD and AdΔHBD were significantly different (P<0.05) from AdEmpty-infected groups. N = 8 per group.