Figure 7.
A. Spontaneous IPSCs mediated by activation of GABAA receptors in cortical pyramidal neurons were recorded by holding the membrane at +20 mV in standard ACSF. Inset shows bursting from the same cell at a faster time scale. B. BIC application eliminated the events, demonstrating they were mediated by GABAA receptors. C. Left bar graph shows that mean frequency of spontaneous IPSCs was higher in cells from α-Syn mice compared to WTs, but the difference was not statistically significant. Right graph shows amplitude-frequency distributions of spontaneous IPSCs. Significant differences between α-Syn and WT mice occurred in events of 20–30 pA. D. Cumulative amplitudes probability distributions were similar. E. Cumulative inter-event interval probability distributions were significantly different for short duration events.