Table 1.
Absolute values of percent labeling within the area of interest
| PBS | Aß-pE3 vaccinated | Percent reduction1 | p value | |
|---|---|---|---|---|
| Prevention trial | ||||
| Hippocampus R1282 IR | 13.0±0.06 | 10.6±0.88 | 18.20±6.82 | 0.0119 |
| pE3-Aß | 0.61±0.02 | 0.39±0.10 | 35.33±15.64 | 0.04 |
| Thio S | 0.72±0.10 | 0.36±0.06 | 49.57±8.11 | 0.02 |
| Cerebellum | ||||
| R1282 IR | 3.4±0.32 | 1.7±0.20 | 51.56±5.96 | 0.005 |
| pE3-Aß | 0.36±0.02 | 0.09±0.02 | 75.55±4.78 | 0.0004 |
| Thio S | 0.17±0.06 | 0.1±0.02 | 43.49±12.02 | 0.13 |
| Therapeutic trial | ||||
| Hippocampus | ||||
| R1282 IR 10.0±0.76 | 7.5±0.66 | 24.80±6.47 | 0.025 | |
| pE3-Aß | 2.2±0.47 | 1.5± 0.18 | 33.84±7.90 | 0.11 |
| Thio S Cerebellum | 1.4±0.25 | 0.7±0.22 | 48.52±14.25 | 0.04 |
| Cerebellum | ||||
| R1282 IR | 3.9±0.29 | 1.5±0.27 | 62.36±7.20 | 0.0005 |
| pE3-Aß | 1.0± 0.14 | 0.6±0.09 | 40.95±8.90 | 0.03 |
| Thio S | 0.76± 0.11 | 0.47±0.06 | 38.34±8.46 | 0.06 |
1
Percent reduction normalized to mean PBS control value.