Fig. 3.
In a therapeutic study initiated well after the onset of cerebral Aβ deposition and gliosis, weekly passive immunization with anti-pE3-Aβ mAb07/1 in 23-monthold APPswe/PS1ΔE9 mice for 7 weeks resulted in the attenuation of pE3-Aβ and general Aβ (R1282 IR) deposition as well as fibrillar amyloid (Thioflavin S) in the hippocampus (a, b) and cerebellum (c, d) compared to PBS control mice. Immunohistochemical results (a, c) and Thioflavin S labeling were quantified by image analysis (b, d). Absolute values are provided in table 1. Scale bars, 200 µm. p values: * p > 0.05; *** p > 0.001; n.s. = nonsignificant (p = 0.11); p = 0.06 (strong trend).