Figure 6.
A, Representative examples of immunostained brain sections of a control rat (a, c, e) and a rat 48 h after SE (b, d, f). Pgp expression is shown in brain capillaries of third cerebellar lobule (a, b), thalamus (c, d), and hippocampus (e, f). Scale bar, 50 μm. B, Pgp expression in endothelial cells of rat brain capillaries in cerebellum [Cer; −9.6 mm relative to bregma, according to Paxinos and Watson (2007)], frontal motor cortex (FMC; +3.2 mm), corpus striatum (CS; −2.3 mm), thalamus (Th; −2.3 mm), and hippocampal subregions [CA1, CA3, dentate gyrus (DG), dentate hilus (Hil); data are means of 3 analyzed brain levels (−2.3, −3.8, −5.8 mm)] of control and post-SE rats. Data are shown as mean ± SD. Significant differences between control and post-SE rats are indicated, *p ≤ 0.05. C, Correlation between SE-induced changes in Pgp expression and changes in compartmental-model-derived efflux rate constant k2 relative to control group in five different brain regions after partial Pgp inhibition. The dashed line indicates the best fit. p value and Pearson's correlation coefficient (r2) are indicated in the graph.