Figure 3.
Distributions of connectivity strengths between schizophrenia clusters and genes previously implicated in schizophrenia and other related disorders. (a) Distributions of connectivity strengths between cluster I and disease sets. (b) Distributions of connectivity between cluster II and disease sets. The x axes show corresponding likelihood scores in the NETBAG+ phenotypic network. Disease sets shown in the figure are an autism network from the analysis of de novo CNVs11, a curated set of autism genes40, two lists of schizophrenia genes37–39 and a list of intellectual disability genes40. The distributions were smoothed using a Gaussian kernel. Vertical dashed lines indicate the median connectivity strength between the schizophrenia clusters identified in the present study and all human genes sequenced in a recent study8.