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RO5527239 promotes PYY secretion in non-human primates. (A) Time course of plasma PYY levels in 6–14-year-old cynomolgus monkeys after single p.o. administration of RO5527239 (10 mg·kg−1; ▴) compared to the corresponding placebo (▵). Study was set up as a randomized crossover design. (B) Time course of relative plasma PYY levels expressed in percent to placebo (▴) and corresponding plasma levels of RO5527239 (◇). All data represent the mean ± SEM (n = 5 per group).
