Figure 6.
Peptide secretion in mouse is dependent on systemic and not intestinal luminal GPBAR1 agonist levels. (A) Plasma PYY levels determined 1 h after administration of RO5527239 (10 mg·kg−1) by either p.o. gavage or i.v. bolus in male 24-week-old GPBAR1-KI mice. (B) RO5527239 plasma levels in the p.o. and i.v. groups. (C) Plasma PYY levels determined 1 h after administration of tauro-RO5527239 (10 mg·kg−1) by either p.o. gavage or i.v. bolus in male 32-week-old GPBAR1-KI mice. (D) tauro-RO5527239 plasma levels in the p.o. and i.v. groups. All data represent the mean ± SEM (n = 6 per group).