Table 8. Non-Hodgkin Lymphoma in the French Cohort of STAT3-Deficient Patients.
| Pt | Age at NHL Diagnosis (yr) | STAT3 Mutation | NHL Type | Immunohistochemistry | Disease Stage | Site Involved | Treatment | Response/Follow-Up |
|---|---|---|---|---|---|---|---|---|
| P12 | 34 | K642E | DLBCL* | CD20+, CD10+,CD5-, Bcl2+, Bcl6+, LMP- | I | Single right inguinal lymph node (8×4×3cm) | R-CHOP 14 × 6 | CR/3 yr |
| P20 | 17 | R382W | Burkitt-like NHL | CD20+, CD10+, Bcl2-, Bcl6+, Ki67 100%, LMP- | I | Single right inguinal lymph node | R-CHOP × 6 (intrathecal CT × 4) | CR/6 yr |
| P25 | 8 | R382W | Burkitt NHL | CD20+, CD30-, Ki67 100%, LMP-, c-myc rearranged | IV | Intraabdominal tumor, mesenteric lymph nodes, bone marrow | French LMB protocol (COP, COPADM, CYM) | CR/14 yr |
| P26 | 21 | V713M | Anaplastic NHL | CD30+, CD15-, ALK-, EMA-, TiA1+, LMP- | IV | Lymph nodes above and below diaphragm, liver, bone marrow | CEEP × 2, MTX + Aracytine × 1, intensification by BEAM with ASCT | CR/2 yr |
Abbreviations: See previous tables. ALK = anaplastic lymphoma kinase, ASCT = autologous stem cell transplantation, BEAM = carmustine + etoposide + cytarabine + melphalan, CEEP = prednisone + Eldisine + cyclophosphamide + epirubicin, CHOP = prednisone + vincristine + cyclophosphamide + Adriamycin, CR = complete remission, CT = chemotherapy, DLBCL = diffuse large B-cell lymphoma, LMB protocol = Lymphome Malin B (French protocol), LMP = latent membrane protein, MTX = methotrexate.
*
___.[AQ][AQ: Pt 12: DLBCL has an asterisk--add footnote or delete asterisk.]