Figure 2.
Schematic representation of the STAT3 gene. Positions of the STAT3 mutations in the DNA binding (DNA) domain, the Src homology 2 (SH2) domain, the transactivation (TA) domain, amino-terminal (AT) domain, or coiled-coil (CC) domain. Underlined mutations were identified in patients from the current study; mutations not underlined were identified in previous studies. [2–4,28,29,33,35,36,41,47,52,55,60-62,70,71] The positions of all known mutations are indicated in amino acid nomenclature, with the exception of mutations starting with c. at the bottom, which are shown in nucleotide nomenclature.