Fig. 3.
Elimination of C3aR increases neutrophil infiltration after intestinal IR. (A) IR increased intestinal MPO activity in WT mice and even more significantly in C3aR−/− mice. (B) Representative sections of ileum showing infiltrating neutrophils in the villi of small intestine (red/pink, arrows). Note the enhanced IR-induced neutrophil infiltration in C3aR−/− mice. (C) Quantitative counts of the stained cells per villus, showing significant increases in C3aR−/− mice compared with WT mice after intestinal IR. n = 6–12/group. Data in A and C are mean ± SEM. *P < 0.05; **P < 0.01. n.s., not significant (P > 0.05). (Scale bar: 20 μm.)