Table 1.
Sensitivity of leukaemic cell lines to PFI-1
| Cell line | Cell type | GI50[μM] |
|---|---|---|
| MV4;11 | childhood B-cell myelomonocytic acute leukaemia (MLL/AF4) | 1.5 ± 1 |
| THP-1 | acute monocytic leukaemia (MLL/AF9) | 4 ± 2 |
| KASUMI-1 | acute myeloid leukaemia with t(8;21) translocation (AML1-ETO) | 0.8 ± 1 |
| NALM-17 | Pre B-blast ALL | 8 ± 4 |
| TOM-1 | Ph1-positive acute lymphoblastic leukaemia (ALL) | 3 ± 5 |
| REH | adult acute lymphoblastic leukaemia (ALL) | 9 ± 4 |
| SD-1 | Epstein-Barr virus immortalised Ph-1 positive ALL | 8 ± 3 |
| NALM-6 | pre-B acute lymphoblastic leukaemia (t(5; 12)(q33; p13)) | 8 ± 3 |
| NOMO-1 | acute monocytic leukaemia (MLL/AF9) | 3 ± 3 |
| SEMKH2 | acute monocytic leukaemia (MLL/AF9) | 2 ± 2 |
| RS4;11 | acute monocytic leukaemia (MLL/AF4) | 2 ± 2 |
| KOCL-45 | acute monocytic leukaemia (MLL/AF4) | 10 ± 5 |
| U937 | leukaemic monocytic lymphoma | 5 ± 3 |
| PL21 | acute promyelolytic leukaemia | 10 ± 5 |
| SUPB-15 | Ph+ childhood B-cell ALL | 11 ± 4 |
| K-562 | erythroleukaemia CML blast (Bcr-ABL) | >20 |