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Diagram depicting the role of decorin in inducing rapid release of thrombospondin-1 (TSP-1) from breast cancer cells via the EGFR. Soluble decorin functions as a partial agonist of EGFR to elicit RhoA degradation via the 26S proteasome. Loss of RhoA leads to deactivation of ROCK1 signaling and mobilization of TSP-1-enriched vesicles. This novel decorin-evoked bioactivity is mediated exclusively through the EGFR but not via the Met receptor. Please refer to text for additional details.
