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. 2013 Apr 16;62(5):1453–1463. doi: 10.2337/db12-1116

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — Dose-dependency study of chronic GcgR activation. Body weight (A), food intake (B), and ad libitum blood glucose (C and D) in response to vehicle (PBS, ○) or 0.3 (●), 1.0 (□), 3.0 (■), or 10 nmol/kg/day (△) IUB288. All treatments were conducted in 11-month-old male C57Bl/6J mice maintained on HFD for 9 months. All data are represented as mean ± SEM; n = 8 per treatment. **P < 0.01; ***P < 0.001 vs. vehicle control, two-way ANOVA with Bonferroni post hoc analysis. Lowercase letters (D) denote statistically similar (P > 0.05) groups, one-way ANOVA with Bonferroni post hoc analysis.