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Netrin-1 suppressed IFNγ-induced cytokine and chemokine production. Bone marrow-derived macrophages were treated with vehicle, netrin-1, IFNγ, or a combination of netrin-1 and IFNγ for 48 h. Cytokine and chemokine levels in the supernatant were determined by ELISA. Netrin-1 suppressed both basal and IFNγ-induced IL-6 (A) and IP-10 (B) production. Values are means ± SE (n = 4). *Significant difference vs. control (P < 0.05). #Significant difference vs. all other groups (P < 0.05).
