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. Author manuscript; available in PMC: 2013 Aug 7.
Published in final edited form as: N Engl J Med. 2013 Feb 7;368(6):551–560. doi: 10.1056/NEJMra1204186

Figure 1. Timelines for Vaccine Development and Licensure of Commercial Vaccines.

Figure 1

Panel A shows major milestones and advances in vaccine development and the cumulative number of licensed vaccines since the time of Edward Jenner’s first use of a vaccination against smallpox in 1796.1 Panel B shows the timeline for licensure of commercial vaccines against the indicated pathogens.2 The abbreviation mAb denotes monoclonal antibody, OspA outer surface protein A, rBS recombinant B subunit of cholera toxin, rDNA recombinant DNA, and WC whole-cell Vibrio cholerae O1.