Table 1. Sample Collections.
Rheumatoid arthritis cases and controls for the Immunochip analysis were assembled from a number of different studies from 6 centres across 5 countries (online methods). Genotype data for additional samples analysed in previously published rheumatoid arthritis ACPA positive GWAS were available from 4 studies. Rheumatoid arthritis cases were classified as anti citrullinated peptide antigen (ACPA) positive and ACPA negative. F:M = female: male.
| Collection | Cases |
Controls | |||||
|---|---|---|---|---|---|---|---|
| All | % Female | ACPA + | ACPA − | % Female | |||
| Immunochip | UK | 3870 | 74 | 2406 | 1000 | 8430 | 53 |
| Swedish EIRA | 2762 | 70 | 1762 | 987 | 1940 | 73 | |
| US | 2536 | 75 | 1803 | 593 | 2134 | 65 | |
| Dutch | 648 | 66 | 330 | 301 | 2004 | 42 | |
| Swedish Umea | 852 | 70 | 524 | 242 | 963 | 69 | |
| Spanish | 807 | 74 | 397 | 216 | 399 | 65 | |
|
|
|||||||
| TOTAL | 11475 | 73 | 7222 | 3339 | 15870 | 57 | |
|
| |||||||
| GWAS | BRASS (US) | 479 | 82 | 479 | - | 1627 | 45 |
| Canada | 586 | 76 | 586 | - | 1553 | 54 | |
| NARAC2 (US) | 746 | 48 | 746 | - | 6567 | 49 | |
| WTCCC (UK) | 552 | 74 | 552 | - | 8125 | 46 | |
|
|
|||||||
| TOTAL | 2363 | 68 | 2363 | - | 17872 | 48 | |
|
| |||||||
| TOTAL | 13838 | 72 | 9585 | 3297 | 33742 | 52 | |