FIGURE 4.
Increased expression of autophagic marker LC3B-II in the retina is associated with light-induced retinopathy in Abca4−/−Rdh8−/− mice. A, expression of LC3B was examined by SDS-PAGE followed by Western blotting with triplicate samples. LC3B-II expression was significantly up-regulated by light 24 h after illumination. *, compared with no light, p < 0.01. B, expression of Atg7 was examined by SDS-PAGE followed by Western blotting with triplicate samples. Shown are retinas of 6-week-old Abca4−/−Rdh8−/− mice after exposure to white light at the intensity of 10,000 lux for 30 min.