. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: Neurobiol Dis. 2012 Nov 29;53:36–48. doi: 10.1016/j.nbd.2012.11.013

Table 1.

Summary of the molecular deficits in cINs found in SCZ patients and the phenotypes observed. Only postmortem studies that included ≥ 10 SCZ and age-matched control brains are included in the table. All postmortem studies controlled for postmortem interval, brain pH or both between SCZ and control subjects. All measurements of mRNA and/or protein were taken from the PFC of postmortem brains (specifically Brodmann’s areas 9, 10 and 46) unless indicated below.

GABAergic cIN deficits	mRNA/protein	Post-mortem SCZ brains	Linkage studies	Behavioral phenotype	Biochemical phenotype	Physiological phenotype
cIN subgroup markers	↓ Parvalbumin	Hashimoto et al., 2003; Beasley et al., 2002; Konradi et al., 2011 ^*
	↓ Somatostatin	Hashimoto et al., 2008a ^*,b; Morris et al. 2008; Konradi et al., 2011 ^
Input synapses (presynaptic changes)	Neuregulin	↑Hashimoto et al., 2004; Law et al., 2006; Chong et al., 2008 ↓Bertram et al., 2007	Stefansson et al., 2002; Harrison et al., 2006; Mei et al., 2008; Walss-Bass et al., 2006	Stefansson et al., 2002; Karl et al., 2007; O’Tuathaigh et al., 2007, 2008, 2010; Duffy et al., 2010; Chen et al., 2008b; Ehrlichman et al., 2009; Deakin et al., 2009; Kato et al., 2010	Hahn et al., 2006; Fazzari et al., 2010; Shibuya et al., 2010	Chen et al., 2010a
Input synapses (postsynaptic changes)	↓ NMDAR			Belforte et al., 2010; Korotkova et al., 2010	Woo et al., 2004, 2008; Bitanihirwe et al., 2009	Homayoun et al., 2007; Belforte et al., 2010, Korotkova et al., 2010
	ErbB4	↑Law et al., 2007; Chong et al., 2008	Silberberg et al., et al., 2006; Nicodemus et al., 2006; Norton et al., 2006; Benzel et al., 2007; Walsh et al., 2008	Stefansson et al., 2002; Golub et al., 2004; Barros et al., 2009; Fazzari et al., 2010; Wen et al., 2010; Chen et al., 2010b	Hahn et al., 2006	Barros et al., 2009; Fazzari et al., 2010; Wen et al., 2010; Chen et al., 2010b
Output synapses (presynaptic changes)	↓GAD67 in PV⁺ cINs	Akbarian et al., 1995; Volk et al., 2000; Guidotti et al., 2000 ^*; Hashimoto et al., 2003, 2008a ^,b; Thompson et al., 2009 ^****; Curley et al., 2011 Woo et al., 1998;
Output synapses (postsynaptic changes)	↓GAT1 in ChC	Pierri et al., 1999; Volk et al., 2001
	↓GABA_A α1 at BC synapses onto PC	Hashimoto et al., 2008a ^**,b; Beneyto et al., 2011; Glausier et al., 2011
	↑GABA_A α2 at ChC synapses onto PC	Volk et al., 2002; Beneyto et al., 2011

Konradi et al., 2011 – only examined the hippocampus.

^**

Hashimoto et al., 2008 – also examined anterior cingulated, M1 and V1.

^***

Guidotti et al., 2000 – also examined cerebellum.

^****

Thompson et al., 2009 – examined PFC and other cortical areas, as well as striatum and thalamus. Chandelier cell, ChC; pyramidal cell, PC; basket cell, BC.