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. 2012 Dec 20;33(3):540–549. doi: 10.1007/s10875-012-9846-1

Table II.

Characteristics of AT patients whose newborn dried blood spots were tested for TRECS

Patient Ethnicity Sex Newborn DBS Age at first symptoms Age at diagnosis of AT First immune panel, showing absolute lymphocyte number/μL at indicated age Earliest AFP, μg/L (age) Normal <8 μg/L for age >2 y Immune and hematologic manifestations Current age or age at death
TREC Actin Result Age T CD4 T B NK
1 White F 3 7,690 Positive 2y 2y 9m 2y 9m 1,162 995 n/a n/a 131 (2y) Lymphoma (6 y), granulomatous skin lesions (3 y) d. 6y 3m
2 Multiple F 7 65,500 Positive 1y 2y 8m 2y 8m 681 373 n/a n/a 60 (2y 8m) bronchiectasis 16y
3 White M 14 16,400 Positive 5y 5y 8m 5y 8m 406 70 42 175 310 (12y 3m) Splenic granulomas (24 y), osteomyelitis (19 y), abdominal Burkitt lymphoma (14 y) 25y
4 Hispanic F 19 33,500 Positive 8y 11y 6m 11y 6m 740 475 142 n/a 62.8 (11y 7m) None 14y 11m
5 Hispanic M 22 20,500 Positive 1y 3y m 3y 4m 443 227 173 421 108.1 (3y 4m) Granulomatous skin lesions 6y 2m
6 Hispanic M 24 36,800 Positive 1y 5m 1y 7m 19m 295 125 100 210 16.8 (1y 7m) None 8y 0m
7 Asian F 25 31,900 Positive 1y 11y n/a n/a n/a n/a n/a 164 (11y 11m) Large B-cell lymphoma (13 y); fungal pneumonia (14 y) 17y
8 Hispanic F 28 14,900 Normal 1y 4m 3y 5m 3y 5m 338 180 128 255 86.8 (3y 7m) None 6y 2m
9 Hispanic F 30 61,300 Normal 3y 11y 10m 12y 463 277 47 n/a 174 (11y 10m) Bronchiectasis 12y 2m
10 Hispanic M 39 34,700 Normal 2y 7y 3m 7y 9m 1,069 534 196 n/a 127 (7y 6m) Recurrent HSV; relapsed AML (10 y) d. 10y 3m
11 Asian F 41 26,100 Normal 10m 1y 6m 23m 176 132 522 n/a 48.7 (1y 9m) None 2y 6m
12 Hispanic F 101 88,100 Normal 1y 2m 2y 11m 6y 11m 861 369 284 n/a 210 (6y 8m) None 8y 4m
13 Hispanic F 216 37,300 Normal 2y 6m 4y 6m 4y 6m 1,571 428 238 n/a 37.6 (4y 6m) Chronic sinusitis and otitis 7y 6m