Table 2.
Putative markers of pluripotency. Of the original 489 gene probes down-regulated in both differentiation conditions, 169 were found to be expressed in somatic tissues at a level less than the 5th percentile observed in hESCs and are designated markers of pluripotency.
| GeneProbe | Gene | Gene_description |
|---|---|---|
| A_32_P74847 | LARP7 | La ribonucleoprotein domain family, member 7 |
| A_24_P668974 | LARP7 | La ribonucleoprotein domain family, member 7 |
| A_24_P383640 | POU5F1P3 | POU class 5 homeobox 1 pseudogene 3 |
| A_32_P211752 | LOC100506507 | Hypothetical LOC100506507 |
| A_32_P132563 | POU5F1 | POU class 5 homeobox 1 |
| A_24_P144601 | POU5F1 | POU class 5 homeobox 1 |
| A_24_P214841 | POU5F1 | POU class 5 homeobox 1 |
| A_23_P327910 | ZIC3 | Zic family member 3 |
| A_23_P140362 | VRTN | Vertebrae development homolog (pig) |
| A_23_P204640 | NANOG | Nanog homeobox |
| A_23_P25587 | LECT1 | Leukocyte cell derived chemotaxin 1 |
| A_23_P329798 | CER1 | Cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis) |
| A_23_P59138 | POU5F1 | POU class 5 homeobox 1 |
| A_23_P72817 | GDF3 | Growth differentiation factor 3 |
| A_23_P380526 | DPPA4 | Developmental pluripotency associated 4 |
| A_32_P135985 | TDGF1 | Teratocarcinoma-derived growth factor 1 |
| A_23_P127322 | NODAL | Nodal homolog (mouse) |
| A_23_P137484 | L1TD1 | LINE-1 type transposase domain containing 1 |
| A_23_P374844 | GAL | Galanin prepropeptide |
| A_23_P366376 | TDGF1 | Teratocarcinoma-derived growth factor 1 |
| A_23_P216149 | TERF1 | Telomeric repeat binding factor (NIMA-interacting) 1 |
| A_24_P357266 | GRPR | Gastrin-releasing peptide receptor |
| A_32_P220696 | TERF1 | Telomeric repeat binding factor (NIMA-interacting) 1 |
| A_23_P137573 | LEFTY2 | Left–right determination factor 2 |
| A_24_P90022 | SEPHS1 | Selenophosphate synthetase 1 |
| A_24_P192434 | TERF1 | Telomeric repeat binding factor (NIMA-interacting) 1 |
| A_23_P207999 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 |
| A_23_P102471 | MSH2 | MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) |
| A_24_P392475 | BPTF | Bromodomain PHD finger transcription factor |
| A_23_P28153 | SCLY | Selenocysteine lyase |
| A_23_P209337 | METTL21A | Methyltransferase like 21A |
| A_24_P50458 | TERF1 | Telomeric repeat binding factor (NIMA-interacting) 1 |
| A_23_P204246 | PHC1 | Polyhomeotic homolog 1 (Drosophila) |
| A_23_P156310 | SKP2 (includes EG:27401) | S-phase kinase-associated protein 2 (p45) |
| A_32_P137926 | MMS22L | MMS22-like, DNA repair protein |
| A_23_P14821 | GABRB3 | Gamma-aminobutyric acid (GABA) A receptor, beta 3 |
| A_32_P87531 | DNAH14 | Dynein, axonemal, heavy chain 14 |
| A_23_P256142 | AKIRIN1 | Akirin 1 |
| A_24_P162929 | METTL21A | Methyltransferase like 21A |
| A_32_P741851 | GLB1L3 | Galactosidase, beta 1-like 3 |
| A_24_P118452 | SEPHS1 | Selenophosphate synthetase 1 |
| A_23_P47058 | CUZD1 | CUB and zona pellucida-like domains 1 |
| A_24_P655268 | LOC729082 | Hypothetical LOC729082 |
| A_24_P916586 | BICD1 | Bicaudal D homolog 1 (Drosophila) |
| A_23_P156842 | EEF1E1 | Eukaryotic translation elongation factor 1 epsilon 1 |
| A_23_P259127 | ESRP1 | Epithelial splicing regulatory protein 1 |
| A_32_P76091 | HSPD1 | Heat shock 60 kDa protein 1 (chaperonin) |
| A_24_P134727 | TFAM | Transcription factor A, mitochondrial |
| A_23_P160336 | LEFTY1 | Left–right determination factor 1 |
| A_24_P244699 | NUDT15 | Nudix (nucleoside diphosphate linked moiety X)-type motif 15 |
| A_24_P52921 | BCAT1 | Branched chain amino-acid transaminase 1, cytosolic |
| A_23_P214907 | MTHFD1L | Methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like |
| A_32_P213091 | SHISA9 | Shisa homolog 9 (Xenopus laevis) |
| A_23_P323094 | PHC1 | Polyhomeotic homolog 1 (Drosophila) |
| A_23_P82823 | PINX1 | PIN2/TERF1 interacting, telomerase inhibitor 1 |
| A_23_P162256 | DENR | Density-regulated protein |
| A_23_P365060 | MDN1 | MDN1, midasin homolog (yeast) |
| A_23_P18818 | CNOT6 | CCR4-NOT transcription complex, subunit 6 |
| A_23_P148484 | RLIM | Ring finger protein, LIM domain interacting |
| A_23_P111373 | MRS2 (includes EG:380836) | MRS2 magnesium homeostasis factor homolog (S. cerevisiae) |
| A_23_P203201 | DDX6 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 |
| A_23_P92410 | CASP3 | Caspase 3, apoptosis-related cysteine peptidase |
| A_23_P216118 | UNC5D | Unc-5 homolog D (C. elegans) |
| A_23_P214111 | KIF13A | Kinesin family member 13A |
| A_23_P138465 | NOLC1 | Nucleolar and coiled-body phosphoprotein 1 |
| A_23_P121423 | CDC25A | Cell division cycle 25 homolog A (S. pombe) |
| A_23_P136504 | SLC25A21 | Solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 |
| A_23_P73220 | FGD6 | FYVE, RhoGEF and PH domain containing 6 |
| A_23_P421436 | ADD2 | Adducin 2 (beta) |
| A_23_P23356 | RRP15 (includes EG:327053) | Ribosomal RNA processing 15 homolog (S. cerevisiae) |
| A_32_P34826 | C21orf88 | Chromosome 21 open reading frame 88 |
| A_24_P128977 | G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 |
| A_23_P405761 | RRAS2 | Related RAS viral (r-ras) oncogene homolog 2 |
| A_23_P70168 | TARS | Threonyl-tRNA synthetase |
| A_24_P415260 | DDX21 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 |
| A_24_P253215 | EMG1 | EMG1 nucleolar protein homolog (S. cerevisiae) |
| A_23_P54834 | NIP7 | Nuclear import 7 homolog (S. cerevisiae) |
| A_23_P155407 | RTP1 | Receptor (chemosensory) transporter protein 1 |
| A_24_P297888 | MTAP | Methylthioadenosine phosphorylase |
| A_23_P351215 | SKIL | SKI-like oncogene |
| A_32_P1614 | LOC100506054 | Hypothetical LOC100506054 |
| A_24_P213794 | CCRN4L | CCR4 carbon catabolite repression 4-like (S. cerevisiae) |
| A_23_P10966 | GABRB3 | Gamma-aminobutyric acid (GABA) A receptor, beta 3 |
| A_23_P160881 | SMPDL3B | Sphingomyelin phosphodiesterase, acid-like 3B |
| A_23_P373119 | HMG4L | High mobility group box 3 pseudogene 1 |
| A_23_P27167 | RNASEH1 | Ribonuclease H1 |
| A_24_P49747 | HMGB3P24 | High mobility group box 3 pseudogene 24 |
| A_23_P213908 | PHAX | Phosphorylated adaptor for RNA export |
| A_23_P358417 | TIMM8A | Translocase of inner mitochondrial membrane 8 homolog A (yeast) |
| A_24_P902052 | SNHG13 | Small nucleolar RNA host gene 13 (non-protein coding) |
| A_24_P24685 | HMGB3P22 | High mobility group box 3 pseudogene 22 |
| A_24_P13533 | LRR1 | Leucine rich repeat protein 1 |
| A_23_P215484 | CCL26 | Chemokine (C–C motif) ligand 26 |
| A_23_P252362 | MRPS30 | Mitochondrial ribosomal protein S30 |
| A_24_P943922 | CACHD1 | Cache domain containing 1 |
| A_32_P194264 | CHAC2 | ChaC, cation transport regulator homolog 2 (E. coli) |
| A_24_P922606 | NUP160 | Nucleoporin 160 kDa |
| A_23_P133216 | NLN | Neurolysin (metallopeptidase M3 family) |
| A_23_P128991 | SLIRP | SRA stem-loop interacting RNA binding protein |
| A_23_P56553 | METTL8 | Methyltransferase like 8 |
| A_23_P355075 | CENPN | Centromere protein N |
| A_23_P134008 | USP45 | Ubiquitin specific peptidase 45 |
| A_23_P41255 | G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 |
| A_23_P145724 | C7orf16 | Chromosome 7 open reading frame 16 |
| A_23_P87759 | EMG1 | EMG1 nucleolar protein homolog (S. cerevisiae) |
| A_23_P56865 | DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 |
| A_24_P134626 | TXLNG | Taxilin gamma |
| A_24_P234196 | RRM2 | Ribonucleotide reductase M2 |
| A_23_P214354 | EXOC2 | Exocyst complex component 2 |
| A_23_P5370 | RPRM | Reprimo, TP53 dependent G2 arrest mediator candidate |
| A_24_P12573 | CCL26 | Chemokine (C–C motif) ligand 26 |
| A_23_P72770 | USP44 | Ubiquitin specific peptidase 44 |
| A_24_P272389 | LOC285216 | Methylenetetrahydrofolate dehydrogenase (NADP+dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene |
| A_23_P54540 | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4 |
| A_24_P347624 | SNURF | SNRPN upstream reading frame |
| A_24_P128085 | RC3H2 | Ring finger and CCCH-type domains 2 |
| A_23_P102183 | PNO1 | Partner of NOB1 homolog (S. cerevisiae) |
| A_32_P71788 | FKBP4 | FK506 binding protein 4, 59 kDa |
| A_23_P204170 | TMPO | Thymopoietin |
| A_32_P44775 | C9orf85 | Chromosome 9 open reading frame 85 |
| A_23_P143958 | RPL22L1 | Ribosomal protein L22-like 1 |
| A_24_P914479 | SNX5 | Sorting nexin 5 |
| A_23_P427217 | JMJD1C | Jumonji domain containing 1C |
| A_23_P204380 | GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits |
| A_24_P344307 | PSME3 | Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) |
| A_24_P100664 | MKKS | McKusick-Kaufman syndrome |
| A_23_P218918 | FGF2 | Fibroblast growth factor 2 (basic) |
| A_24_P314477 | TUBB2B | Tubulin, beta 2B |
| A_24_P15754 | TOMM40 | Translocase of outer mitochondrial membrane 40 homolog (yeast) |
| A_23_P37497 | MYO1E | Myosin IE |
| A_24_P143843 | LOC729566 | Zinc finger and BTB domain containing 8 opposite strand pseudogene 1 |
| A_24_P152404 | C10orf76 | Chromosome 10 open reading frame 76 |
| A_23_P125001 | RAC3 | Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| A_23_P135063 | ||
| A_24_P161773 | ||
| A_24_P178523 | ||
| A_24_P179646 | ||
| A_24_P195286 | ||
| A_24_P221285 | ||
| A_24_P340659 | ||
| A_24_P341106 | ||
| A_24_P341731 | ||
| A_24_P358302 | ||
| A_24_P367326 | ||
| A_24_P392505 | ||
| A_24_P410000 | ||
| A_24_P41189 | ||
| A_24_P455060 | ||
| A_24_P560332 | ||
| A_24_P58597 | ||
| A_24_P67063 | ||
| A_24_P67681 | ||
| A_24_P695223 | ||
| A_24_P707102 | ||
| A_24_P711050 | ||
| A_24_P752362 | ||
| A_24_P76142 | ||
| A_24_P901084 | ||
| A_24_P928765 | ||
| A_32_P104334 | ||
| A_32_P146320 | ||
| A_32_P152696 | ||
| A_32_P157504 | ||
| A_32_P207147 | ||
| A_32_P24068 | ||
| A_32_P63086 | ||
| A_32_P65691 | ||
| A_32_P885123 | ||
| A_32_P89049 |