Figure 6.
Signatures of Mutational Processes Extended to Include Additional Sequence Context
(A) Signature 2 deciphered from the base substitutions (including the two bases 5′ and 3′ to each mutated base resulting in 1,536 possible mutated pentanucleotides) identified in 21 breast cancer genomes.
(B) Detailed view of C > T mutation types in Signature 2. Purine nucleotides located two bases 5′ of the mutated base are shown in green whereas pyrimidine nucleotides are in red.
(C) Summary of all mutation types caused by Signature 2.
The error bars represent the SD of the contributions for each mutation type for the deciphered signature.