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. Author manuscript; available in PMC: 2014 Jan 18.
Published in final edited form as: Circ Res. 2012 Nov 19;112(2):289–297. doi: 10.1161/CIRCRESAHA.111.300003

Figure 4. PDE3A ablation increases SR Ca2+ content and SERCA2a function.

Figure 4

A) Representative traces depicting Ca2+ release from the SR (transients at the top) and accompanying INCX (bottom) induced by application of 20mmol/L caffeine to WT and PDE3A−/− cardiomyocytes, and then following perfusion with 10 μmol/L milrinone. B) Average data illustrating the effects of PDE3 inhibition with 10μmol/L milrinone (+Mil) or PDE3A ablation on SR Ca2+ content as gauged by integrating INCX (n-values indicated). *p<0.05 versus WT control.