Table 1.
Patient and Operative Characteristics
| Parameter | EPO group, n = 32 | Placebo Group, n = 27 | P Value |
|---|---|---|---|
| HLHS (no., %) | 16 (50%) | 10 (37%) | 0.420 |
| D-TGA (no., %) | 9 (28%) | 12 (44%) | - |
| AA+VSD/other 2V (no., %) | 7 (22%) | 5 (19%) | - |
| CPB time (min) † | 191 (163–236) | 194 (169–270) | 0.382 |
| Aortic crossclamp time (min) † | 98 (84–129) | 104 (89–148) | 0.334 |
| DHCA time (min) † | 9 (8–14) (n=19) | 11 (8–14) (n=10) | 0.562 |
| RCP time (min) | 67.0 ± 30.7 (n=23) | 67.9 ± 31.2 (n=14) | 0.930 |
| Lowest CPB temp (° C) † | 17.9 (17.4–22.8) | 18.1 (17.6–24.9) | 0.266 |
| OR fentanyl dose (mcg/kg) † | 182 (154–291) | 198 (158–295) | 0.755 |
| OR midazolam dose (mg/kg) | 0.96 ± 0.46 | 1.21 ± 0.49 | 0.044* |
| Aprotinin use (no., %) | 11 (34%) | 10 (37%) | 0.952 |
| Isoflurane MAC-hours | 1.78 (0.96–2.29) | 1.58 (1.14–2.68) | 0.879 |
| Mean rSO2 (%) | 69.6 ± 7.1 | 71.2 ± 7.4 | 0.394 |
Abbreviations: HLHS, hypoplastic left heart syndrome; D-TGA, dextrotransposition of the great arteries; AA+VSD, hypoplastic aortic arch/ventricular septal defect; CPB, cardio-pulmonary bypass; OR, operating room; DHCA, deep hypothermic circulatory arrest; RCP, regional cerebral perfusion; MAC, minimum alveolar concentration; rSO2, regional cerebral oxygen saturation. Data are mean ± standard deviation if normally distributed;
†
, data not normally distributed: median (25th–75th percentiles).
*
p<0.05.