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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Immunol Rev. 2013 Mar;252(1):24–40. doi: 10.1111/imr.12037

Fig. 1. ‘Classical’ model of the role of master regulators for CD4+ T-cell differentiation.

Fig. 1

From the classical monolithic perspective, each helper cell subset expresses a lineage-defining ‘master regulator’ transcription factor, which is necessary and sufficient to induce each subsets specific gene-expression.