. Author manuscript; available in PMC: 2013 Feb 19.

Published in final edited form as: Mol Cell Neurosci. 2010 Aug 11;46(1):45–54. doi: 10.1016/j.mcn.2010.08.005

Table 1.

Comparison of the phenotypes of KALRN KO and Δkalirin-7 mutant mice.

phenotype	KALRN KO	Δkalirin-7
*Biochemistry*
kalirin-5, kalirin-7 protein level	absent	absent
kairin-9, kairin-12 protein level	absent	50% increase
net kalirin protein levels	absent	75% of WT
Rac1 activity - cortex	reduced	normal
Rac1 activity - hippocampus	normal	ND
*Cellular morphology*
gross morphology - cortex	smaller in KO	normal
gross morphology - hippocampus	smaller in KO	normal
spine density - cortex	∼ 60% of WT	ND
spine density - hippocampus	normal	85% of WT
presynaptic marker - cortex	normal	ND
presynaptic marker - hippocampus	normal	slight decrease^*
postsynaptic marker - cortex	normal	ND
postsynaptic marker - hippocampus	normal	slight decrease^*
dendrite complexity - cortex	reduced	ND
dendrite complexity - hippocampus	normal	ND
spine density in cortical culture	∼ 60% of WT	reduced
spine density in hippocampal culture	normal	ND
dendrite complexity - cortex	reduced	ND
dendrite complexity - hippocampus	normal	ND
spine density in cortical culture	∼ 60% of WT	reduced
spine density in hippocampal culture	normal	ND
dendrite complexity - cortex	reduced	ND
dendrite complexity - hippocampus	normal	ND
dendrite complexity in cortical culture	reduced	ND
dendrite complexity in hippocampal culture	normal	ND
*Electrophysiology*
AMPA mEPSC cortex	reduced	ND
basal transmission hippocampus	normal	normal
LTP hippocampus	reduced	reduced
paired pulse facilitation	reduced	ND
*Behavior*
contextual fear conditioning	impaired	impaired
cued fear conditioning	impaired	ND
short-term memory	impaired	normal
long-term memory	normal	normal
social behavior	impaired	ND
pre-pulse inhibition	impaired	ND
anxiety-like behavior	ND	reduced
locomotor activity	increased	normal (open field)

data not shown in Ma et al., 2008; ND, not determined