Fig. 1.
C9ORF72 is structurally homologous to DENN-like proteins. Probabilities of shared structure (pSS) of pairwise comparisons of sequences by HHpred, comparing in (A): C9ORF72, FLCN, LCHN, two AVL9 sequences (human Hs, yeast Sc), DENND1B; and in (B): FLCN, SMcr8, NPRL2, DENND1B, C9ORF72, FNIP (worm). Values are the maximum pSS obtained after optimizing searches. For details of query alignments and hits, see Supplementary Table S2. Variations: * match is to PDB entry for FLCN; • match is to worm C9ORF72. Self-searches all give pSS = 100%