Figure 6. Association between SNPs and gene expression.
a, b, SNP distribution around TSS (a) and TES (b) of the associated genes based on several Wald test P-value cut offs after gene-wide Bonferroni correction. c, GLIPR1L2 expression association with rs10785190 genotype, a SNP located in exon 1. The horizontal solid and dashed LOWESS curves are the developmental trend of gene and exon 1 and 2 expression, respectively. d, qRT-PCR validation of exon 1 and 2 expression in NCX for each genotype (N=14 GG, 14 AG, 8 AA) plotted relative to the local regression smooth curve to facilitate comparison across developmental periods. P-values were calculated by unpaired t-test. Whiskers indicate 5th and 95th percentile.