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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Nature. 2007 Nov 29;450(7170):741–744. doi: 10.1038/nature05998

Figure 3. Inhibition of the EGFR kinase activity by Mig6segment 1–2.

Figure 3

a, Inhibition of the L834R mutant kinase in solution by peptides 336–412, 336–412(Y358A) (containing both segment 1 and 2). The 30-residue peptide (containing segment 1 only) is used as a control. The insert shows an expanded view at low peptide concentrations. b, Inhibition of the wild type kinase in solution by peptides 336–412 and 336–412(Y358A). Titration of peptide 336–412 beyond 20 μM leads to unreliable results due to precipitation of the protein and peptide (See Method).