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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Hepatology. 2012 Feb;55(2):594–608. doi: 10.1002/hep.24701

Figure 5. SAM protects WT mice from CCl4-induced chronic liver injury.

Figure 5

C57BL/6J WT mice were injected MO, SAM plus MO, CCl4 or CCl4 plus SAM for 1 month. Co-treated mice showed decreased OPN expression (A), which was quantified by morphometry analysis (B). Likewise, fibrosis was less apparent in co-treated mice than in CCl4-injected mice as shown by Sirius red/fast green staining (C) and morphometry analysis (D). Results are expressed as mean values ± SEM. n=8/group; ***p<0.001 for CCl4 or CCl4 + SAM vs MO or SAM; ••p<0.01 for CCl4 + SAM vs CCl4.