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. Author manuscript; available in PMC: 2013 May 22.
Published in final edited form as: ACS Nano. 2012 Apr 24;6(5):3954–3966. doi: 10.1021/nn300149c

Scheme 1.

Scheme 1

Drug/dye-silica nanoconjugate. Schematic illustration of the synthesis of drug/dye-silica nanoconjugates (NCs). The Stöber method (St) or the reverse microemulsion method (Trx) (I) was used to prepare drug/dye-silica NCs followed by in situ surface PEGylation (II). For NCs formed via the St method, TEOS was used in a solution of NH4OH/MeOH in the presence of 1, 4 or 5 or in a solution of NaF/MeOH in the presence of 2, 3 or 7. For NCs prepared via the Trx method, 8 or 9 was used in conjunction with 2 or 3 to synthesize the corresponding NCs.