Figure 6. DAC and the JAK-STAT activator interferon-γ have an additive anti-proliferative effect on PDAC cells.
Primary PDAC epithelial cells isolated from the KPC-Brca1 mice and grown in short-term culture were treated for 4 days with the indicated single agents or combinations of low-dose DAC (0.5 μM) and interferon-γ (100 ng/ml) as described in Methods, followed by MTT assays for relative numbers of viable cells. The results show an additive anti-proliferative effect of DAC plus interferon-γ.
