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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: J Immunol. 2012 Nov 12;189(12):5786–5796. doi: 10.4049/jimmunol.1202195

Figure 1. TLR7 Transgenic (Tg7) mice are similar in expression and function to Yaa mice.

Figure 1

BAC RP23-92P6 was modified as described in the methods to include 2 loxP sites, flanking the TLR7 gene (A). Mice carrying the transgene carried two additional genomic DNA copies (B). Multiple founders (Fn) show 2x TLR7 expression compared to B6 mice (C). Male mice (Fn1 shown) were examined for an increase in the TLR7 functional response. Tg7 (Fn1) mice demonstrate an increase in CD69+ B cells (B220+ cells) after TLR7 stimulation, by R837 (D) and enhanced proliferation of B cells, by R848 as detected by CFSE dilution (E). 2 way ANOVA demonstrated significance for both D and E, post hoc significance is shown by *, p<0.05. Bars represent SEM, n=3 mice per strain in each separate experiment.