Table 1.
Subject Characteristics, Mean ± SD (range)
| NC (n = 15) | ALC (n = 15) | t(28)a | p-value (2-tailed) | |
|---|---|---|---|---|
| Age | 54.1 ± 12.5 (25–77) | 50.2 ± 12.8 (34–76) | −0.85 | 0.40 |
| Education | 14.7 ± 1.8 (12–18) | 13.8 ± 1.7 (12–18) | −1.28 | 0.21 |
| Full scale IQ | 109.1 ± 9.8 (88–123) | 105.5 ± 7.8 (90–116) | −1.12 | 0.27 |
| Verbal IQ | 109.1 ± 10.1 (92–128) | 106.6 ± 8.7 (92–121) | −0.71 | 0.48 |
| Performance IQ | 107.7 ± 11.1 (83–125) | 103.1 ± 9.6 (83–113) | −1.19 | 0.24 |
| Working memory | 108.4 ± 15.3 (83–136) | 113.3 ± 19.4 (83–155) | 0.74 | 0.46 |
| Verbal fluency | 44.3 ± 19.5 (10–80) | 43.1 ± 27.2 (10–80) | −0.24 | 0.81 |
| POMS – Depress. | 37.8 ± 5.0 (35–50) | 39.5 ± 8.2 (30–66) | 0.7 | 0.49 |
| POMS – Anx. | 40.3 ± 4.7 (37–53) | 42.0 ± 4.7 (32–53) | 0.4 | 0.69 |
| MAACL – Depr. | 46 ± 3.3 (40–53) | 46 ± 8.1 (40–71) | 0.0 | 1.0 |
| MAACL – Anx. | 43.7 ± 2.3 (37–45) | 43.5 ± 5.8 (37–58) | −0.15 | 0.88 |
| Hamilton Depr. | 0.93 ± 1.14 (0–3) | 1.6 ± 2.2 (0–8) | 1.08 | 0.29 |
| QFI | 0.4 ± 0.6 (0–2.0) | 11.9 ± 10.5 (1.0 –38.0) | 3.89 | 0.0006 |
| Years of ≥21 drinks/week | N/A | 16.4 ± 8.7 (5–35) | N/A | N/A |
| Years sober | N/A | 7.3 ± 12.0 (0.2–38) | N/A | N/A |
| FH+ first degree relatives | 21% | 73% | Fisher’s ET | <0.01 |
| FH+ fathers | 21% | 60% | Fisher’s ET | <0.06 |
| FH+ mothers | 0% | 20% | Fisher’s ET | 0.25 |
| ASPD symptoms | 14% | 67% | Fisher’s ET | <0.01 |
QFI, Quantity-Frequency Index was calculated based on the amount, type, and frequency of use of alcoholic beverages either over the last 6 months (for the nonalcoholics), or over the 6 months preceding cessation of drinking (for the alcoholics). FH+ denotes group percentages reporting Family History of alcoholism depending on the affected relative. Fisher’s ET (Exact Test) is used to calculate statistical significance of categorical data obtained from small samples.
a
Cognitive and affective scores and QFI were not recorded for 1 control subject; therefore, t(27) is listed.