FIGURE 8.
Model showing the effect of miR-182-5p on the DNA repair pathway. When a cell undergoes double-strand breaks (DSB), “sensor” genes activate a signaling cascade including transducer and effector genes that leads to an efficient repair of the DNA damage. Under this model, miR-182-5p-mediated deregulation of the DNA damage response pathway (orange) typically results in impaired DNA repair with subsequent effects on the cell cycle, apoptosis, or genetic stability leading to tumorigenesis. We have also highlighted previously validated and novel targets that we have mechanistically shown to interact with miR-182-5p, belonging to the DNA damage response pathway.