. Author manuscript; available in PMC: 2014 Mar 1.

Published in final edited form as: Behav Brain Res. 2012 Nov 29;240:119–133. doi: 10.1016/j.bbr.2012.11.028

Table 2.3.

Effects of nicotine (300 μg/kg, n=7) and ABT-418 (12, n=7; 40, n=7; and 120 μg/kg, n=7) treatment on the effects of scopolamine (1 mg/kg) pretreatment on mouse performance of the 5C-CPT.

Measure	Treatment	Mean	s.e.m.		d.f.	F	p value
Premature Responses	veh+veh	2.79	2.70	Drug	(5,31)	5.0	<0.005
	scop+veh	22.17	2.91^*	Drug × vSD	(10,62)	<1	Ns
	scop+nic_300μg/kg	10.22	2.91	vSD	(2,62)	<1	Ns
	scop+abt_12μg/kg	8.82	2.91^†
	scop+abt_40μg/kg	13.11	2.91
	scop+abt_120μg/kg	12.60	2.91

Accuracy	veh+veh	0.966	0.021	Drug	(5,31)	3.7	<0.05
	scop+veh	0.854	0.023^*	Drug × vSD	(10,62)	<1	Ns
	scop+nic_300μg/kg	0.858	0.023^*	vSD	(2,62)	18.3	<0.0001
	scop+abt_12μg/kg	0.875	0.023^*
	scop+abt_40μg/kg	0.904	0.023
	scop+abt_120μg/kg	0.905	0.023

% Omissions	veh+veh	25.75	5.13	Drug	(5,31)	2.6	<0.05
	scop+veh	43.65	5.54	Drug × vSD	(10,62)	185	<0.0001
	scop+nic_300μg/kg	48.54	5.54	vSD	(2,62)	<1	Ns
	scop+abt_12μg/kg	45.97	5.54
	scop+abt_40μg/kg	42.90	5.54
	scop+abt_120μg/kg	47.26	5.54

Mean Correct Latency (ms)	veh+veh	935	57	Drug	(5,31)	<1	Ns
	scop+veh	940	62	Drug × vSD	(10,62)	55.8	<0.0001
	scop_nic_300μg/kg	972	62	vSD	(2,62)	<1	Ns
	scop+abt_12μg/kg	920	62
	scop+abt_40μg/kg	956	62
	scop+abt_120μg/kg	888	62

Mean False Alarm Latency (ms)	veh+veh	720	70	Drug	(5,31)	1.4	Ns
	scop+veh	950	75	Drug × vSD	(10,62)	1.8	<0.1
	scop+nic_300μg/kg	889	89	vSD	(2,62)	<1	Ns
	scop+abt_12μg/kg	791	75
	scop+abt_40μg/kg	761	75
	scop+abt_120μg/kg	753	75

Total Trials	veh+veh	229.9	9.2	Drug	(5,31)	1.6	Ns
	scop+veh	241.0	9.9	Drug × vSD	(10,62)	1.3	Ns
	scop+nic_300μg/kg	221.4	11.7	vSD	(2,62)	1.5	Ns
	scop+abt_12μg/kg	227.3	9.9
	scop+abt_40μg/kg	228.7	9.9
	scop+abt_120μg/kg	236.7	9.9

denotes p<0.05 when compared to vehicle treated mice (n=8), Ns denotes not significant.