TABLE 2.
RELATIVE EXPRESSION OF EXTRACELLULAR MATRIX PROTEINS IN ACELLULAR IPF LUNG COMPARED TO ACELLULAR NORMAL LUNG
| Protein | Fold Change (IPF:Normal) |
| Hyaluronan and proteoglycan link protein 1 | 21.20 |
| Matrix Gla protein | 19.33 |
| Latent-transforming growth factor β-binding protein 1 | 15.83 |
| Microfibrillar-associated protein 2 | 8.08 |
| Nephronectin | 5.67 |
| Fibrillin-2 | 4.73 |
| Periostin | 3.49 |
| EGF-containing fibulin-like extracellular matrix protein 1 | 3.25 |
| Fibrillin-1 | 3.18 |
| Fibulin-5 | 3.11 |
| Collagen α-1(III) chain | 2.72 |
| Fibulin-2 | 2.60 |
| Deleted in malignant brain tumors 1 protein | 2.56 |
| Dermatopontin | 2.53 |
| Versican core protein | 2.47 |
| Metalloproteinase inhibitor 3 | 2.37 |
| Collagen α-1(VIII) chain | 2.29 |
| Tubulointerstitial nephritis antigen-like | 1.72 |
| Collagen α-2(VI) chain | 1.72 |
| Asporin | 1.71 |
| Transforming growth factor-β–induced protein ig-h3 | 1.62 |
| Microfibrillar-associated protein 5 | 1.57 |
| Collagen α-1(VI) chain | 1.54 |
| Collagen α-1(XIV) chain | 1.54 |
| Annexin A1 | 1.51 |
| Microfibril-associated glycoprotein 4 | 1.46 |
| Aggrecan core protein | 1.39 |
| Collagen α-3(VI) chain | 1.31 |
| Collagen α-5(VI) chain | 1.30 |
| Cartilage acidic protein 1 | 1.28 |
| Inter-α-trypsin inhibitor heavy chain H4 | 1.26 |
| Collagen α-2(IV) chain | 1.20 |
| Vitronectin | 1.18 |
| α1-antitrypsin | 1.10 |
| Collagen α-1(I) chain | 1.02 |
| Mimecan | 1.01 |
| Collagen α-1(IV) chain | 0.99 |
| Basement membrane-specific heparan sulfate proteoglycan core protein | 0.92 |
| Nidogen-1 | 0.89 |
| Protein AMBP | 0.86 |
| Collagen α-6(VI) chain | 0.86 |
| Annexin A2 | 0.81 |
| Tenascin | 0.79 |
| Fibrinogen γ chain | 0.76 |
| Elastin | 0.73 |
| Fibronectin | 0.72 |
| Annexin A7 | 0.71 |
| Annexin A5 | 0.70 |
| EMILIN-1 | 0.67 |
| Fibrinogen β chain | 0.67 |
| Fibrinogen α chain | 0.67 |
| Collagen α-2(I) chain | 0.66 |
| Decorin | 0.62 |
| Neutrophil elastase | 0.61 |
| Laminin subunit γ-1 | 0.61 |
| Fibulin-1 | 0.60 |
| Collagen α-1(XII) chain | 0.58 |
| Laminin subunit α-5 | 0.57 |
| Laminin subunit β-2 | 0.46 |
| Lumican | 0.44 |
| Nidogen-2 | 0.44 |
| Tenascin-X | 0.43 |
| Laminin subunit β-1 | 0.43 |
| Inter-α-trypsin inhibitor heavy chain H1 | 0.43 |
| Biglycan | 0.37 |
| Leukocyte elastase inhibitor | 0.34 |
| Collagen α-1(XV) chain | 0.33 |
| Laminin subunit γ-2 | 0.32 |
| Laminin subunit β-3 | 0.31 |
| Collagen α-1(XVIII) chain | 0.29 |
| Laminin subunit α-4 | 0.28 |
| Prolargin | 0.25 |
| α1-antichymotrypsin | 0.25 |
| Latent-transforming growth factor β-binding protein 2 | 0.24 |
| Annexin A4 | 0.21 |
| Laminin subunit α-2 | 0.17 |
| Laminin subunit α-3 | 0.14 |
| EGF-containing fibulin-like extracellular matrix protein 2 | 0.13 |
| Agrin | 0.06 |
| Annexin A6 | 0.58 |
| Fibromodulin | 0.05 |
Definition of abbreviation: IPF = idiopathic pulmonary fibrosis.