Fig. 1.
Differential gene expression in leukocytes from mother-reared vs. surrogate/peer-reared macaques. (A) Heat plot representation of gene expression values for 249 transcripts showing a twofold or greater difference in average expression between peripheral blood mononuclear cells (PBMCs) from surrogate/peer-reared (SPR) rhesus macaques and those from maternally reared (MR) rhesus macaques. Rows, animals; columns, gene transcripts; red, up-regulated gene expression; green, down-regulated gene expression. (B) Transcript origin analyses assessing cellular origins of differentially expressed genes within specific PBMC subsets. (C) Relative prevalence of binding motifs for NF-κB, IRF, CREB, and GR transcription factors within promoters of genes up-regulated in PBMCs from SPR vs. MR animals.