Fig. 2.
Schematic representation of vinculin cycling between active and inactive conformations. D1–D5 correspond to the individual domains of vinculin. D1–D4 assemble to form a globular head region which is connected by a flexible proline-rich neck to the vinculin tail, the D5 domain. A subset of binding partners that are thought to control together with vinculin the formation of FA are shown on the vinculin panel representing the active form. Partners involved in the activation of vinculin are in bold italic.