Table 1.
Different putative Aβ oligomer receptors in neurons.
| Synaptic protein | Type of Aβ aggregate | Kd | Reference |
|---|---|---|---|
| α7AChR | 42 Monomer | 4.1 pM | Wang et al. (2000) |
| α4β2AChR | 42 Monomer | 30 nM | |
| AChE | 12–48 fragment | – | Alvarez et al. (1997) |
| Fz5-CRD | 40 Monomer | 0.105 μM | Magdesian et al. (2008) |
| Fz5-CRD | 42 Monomer | – | |
| Fz5-CRD | ADDL | – | |
| Fz5-CRD | Fibril | – | |
| PrPc | Oligomer | 92 nM | Lauren et al. (2009) |
| NMDAR | ADDL | – | De Felice et al. (2007) |
| TNF-R | 40 Monomer | 4.2 pM | Li et al. (2011) |
| α2β1 integrin | 40 Monomer | – | Wright et al. (2007) |
| αVβ1 integrin | 40 Monomer | – | |
| APP | Fibril | – | Lorenzo et al. (2000) |
| NL-1 | Monomer/oligomer | 0.75 μM | Dinamarca et al. (2011) |
The Table presents the main putative receptors that bind or interact with different types of Aβ aggregates, in some cases the dissociation constant (Kd) is included. In other cases, it shows protein that are not receptors, for example AChE and the APP, both proteins interacts with Aβ aggregates.